Across TCGA pan-cancer cohorts, NELL2 mass-spec protein differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of NELL2’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where NELL2 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types NELL2 is over-expressed in tumor, although a few such as HNSC show the opposite, repressed pattern.

LSCC and HNSC are the cancer types where NELL2 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NELL2 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LSCC	All	All	+0.487	<.001	7	view →
HNSC	Female	All	−1.325	.018	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 2 strongest of 2 lineages.

Exploration

Same gene, other analysis: NELL2 RNA expression & survival · all NELL2 data types