NELL2

mutation — cross-omics
Cross-omicsMUTATION → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, NELL2 mutation is significantly associated with the RNA expression of many other genes, with 2,653 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NELL2-associated genes across cancer lineages are CORO2B, FCER1A, and LINC00865. Each is linked with NELL2 in more than 3 cancer types. Because this analysis shows association rather than direction, both NELL2-to-partner and partner-to-NELL2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NELL2→partner) and Y-score (partner→NELL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
LUADCORO2B →-0.641-3.988.001<.00134
LUADFCER1A →-1.422-2.895.001.00134
UCECLINC00865 →-0.547-1.874.001<.00134
LUSCLINC00886 →-0.462-2.274.007.00634
LUADPOLE2 →+0.699+4.011.001<.00133
LUADRPS19 →+0.469+2.602.008.00633
Each partner links to its Q-omics profile. Showing the 6 strongest of 2,653 associations by consensus.

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