Across TCGA patient cohorts, NELFE mutation is significantly associated with the total protein of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NELFE-associated genes across cancer lineages are Caspase-7-cleavedD198, EGFR_pY1068, and Gab2. Each is linked with NELFE in more than 1 cancer types. Because this analysis shows association rather than direction, both NELFE-to-partner and partner-to-NELFE results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NELFE→partner) and Y-score (partner→NELFE) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+1.100	+3.189	<.001	.010	3	2
UCEC	EGFR_pY1068 →	-0.269	-3.169	.026	.019	3	1
UCEC	Gab2 →	+0.390	+2.459	.023	.020	3	1
UCEC	Notch1 →	+0.163	+2.459	.016	.020	3	1
UCEC	Bcl-2 →	-0.346	-2.432	.039	.020	3	1
UCEC	C-Raf →	+0.209	+3.000	.002	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

Exploration

NELFE survival (RNA) · tumor vs normal (RNA) · all NELFE data types