NELFCD

Across TCGA patient cohorts, NELFCD mutation is significantly associated with the total protein of many other genes, with 36 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NELFCD-associated genes across cancer lineages are GAPDH, PCNA, and Shc_pY317. Each is linked with NELFCD in more than 1 cancer types. Because this analysis shows association rather than direction, both NELFCD-to-partner and partner-to-NELFCD results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GAPDH grouped by NELFCD-low versus NELFCD-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NELFCD→partner) and Y-score (partner→NELFCD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GAPDH →	+0.518	+2.700	.008	.005	3	2
UCEC	PCNA →	+0.228	+1.847	.003	.008	3	2
UCEC	Shc_pY317 →	-0.123	-1.807	.027	.025	3	2
UCEC	STAT3_pY705 →	-0.259	-1.896	.007	.015	3	2
UCEC	ASNS →	+0.465	+1.807	<.001	.025	3	2
UCEC	ATM →	-0.384	-1.847	.021	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

GAPDH by NELFCD expression — UCEC

Explore this box plot interactively →