Across TCGA pan-cancer cohorts, NELFB mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated NELFB data layer compared with 30 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher NELFB mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated NELFB expression acts as an unfavorable survival marker, although some lineages such as CCRCC and LSCC show a favorable association.

CCRCC, LSCC, and GBM are the cancer types where NELFB mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Quartile	III,IV	0.985	0.514	.002	22	view →
LSCC	OS	Tertile	II,III,IV	0.941	0.614	.011	18	view →
GBM	OS	Quartile	All	0.561	0.261	.019	4	view →
HNSC	OS	Median	III,IV	0.802	0.593	.031	1	view →
PDAC	OS	Median	All	0.757	0.887	.030	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: NELFB tumor-vs-normal RNA expression · all NELFB data types