NEK9

Across TCGA patient cohorts, NEK9 mutation is significantly associated with the RNA expression of many other genes, with 2,310 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NEK9-associated genes across cancer lineages are RN7SL134P, RNU4-65P, and TRAJ25. Each is linked with NEK9 in more than 2 cancer types. Because this analysis shows association rather than direction, both NEK9-to-partner and partner-to-NEK9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL134P grouped by NEK9-low versus NEK9-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NEK9→partner) and Y-score (partner→NEK9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RN7SL134P →	+0.092	+3.477	.004	.009	3	3
BLCA	RNU4-65P →	+0.467	+5.147	<.001	.003	3	3
UCEC	TRAJ25 →	+0.182	+2.136	.001	.002	3	3
PRAD	MTND5P22 →	+0.604	+7.939	<.001	.008	3	3
PRAD	TRIM64EP →	+0.068	+7.939	<.001	.008	3	2
UCEC	TRIM36 →	+0.642	+2.329	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,310 associations by consensus.

RN7SL134P by NEK9 expression — BRCA

Explore this box plot interactively →