NEK9

Across TCGA patient cohorts, NEK9 mutation is significantly associated with the total protein of many other genes, with 47 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NEK9-associated genes across cancer lineages are JNK_pT183_Y185, Caspase-8, and ER-alpha_pS118. Each is linked with NEK9 in more than 1 cancer types. Because this analysis shows association rather than direction, both NEK9-to-partner and partner-to-NEK9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK_pT183_Y185 grouped by NEK9-low versus NEK9-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NEK9→partner) and Y-score (partner→NEK9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK_pT183_Y185 →	-0.198	-1.986	<.001	<.001	3	2
UCEC	Caspase-8 →	-0.181	-1.253	.026	.049	3	2
COAD	ER-alpha_pS118 →	+0.134	+2.815	.032	.036	3	2
COAD	Caspase-7-cleavedD198 →	+1.018	+2.815	.019	.036	3	2
UCEC	eIF4E →	+0.209	+3.713	.002	<.001	3	2
UCEC	RAD51 →	+0.113	+2.415	.012	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 47 associations by consensus.

JNK_pT183_Y185 by NEK9 expression — UCEC

Explore this box plot interactively →