NEK9

Across TCGA cell cohorts, NEK9 mutation is significantly associated with the RNA expression of many other genes, with 77 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NEK9-associated genes across cancer lineages are SMIM23, NEUROD4, and ZAN. Each is linked with NEK9 in more than 1 cancer types. Because this analysis shows association rather than direction, both NEK9-to-partner and partner-to-NEK9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SMIM23 grouped by NEK9-low versus NEK9-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NEK9→partner) and Y-score (partner→NEK9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	SMIM23 →	+0.015	+4.569	<.001	.003	3	2
BLOOD_Myeloma	NEUROD4 →	+0.006	+4.807	<.001	.006	3	1
SKIN	ZAN →	+0.006	+6.022	<.001	.001	3	1
SKIN	TMEM210 →	+0.034	+5.415	<.001	.004	3	1
SKIN	CYP2A13 →	+0.065	+4.977	<.001	.007	3	1
SKIN	DPPA5 →	+0.049	+5.415	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 77 associations by consensus.

SMIM23 by NEK9 expression — BLOOD_Leukemia

Explore this box plot interactively →