NEK7

Across TCGA pan-cancer cohorts, NEK7 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated NEK7 data layer compared with 26 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher NEK7 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated NEK7 expression acts as an unfavorable survival marker.

UCEC, LUAD, and GBM are the cancer types where NEK7 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Median	II,III,IV	0.510	1.000	.002	34	view →
LUAD	OS	Median	III,IV	0.308	1.000	.001	20	view →
GBM	OS	Median	All	0.774	0.938	.005	3	view →
LSCC	DFS	Quartile	III,IV	0.390	0.859	.030	3	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

NEK7–UCEC (OS)

Open the UCEC breakdown →