NEK7

Across TCGA patient cohorts, NEK7 mutation is significantly associated with the RNA expression of many other genes, with 645 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NEK7-associated genes across cancer lineages are RNU6-650P, BLOC1S2P1, and RN7SL728P. Each is linked with NEK7 in more than 1 cancer types. Because this analysis shows association rather than direction, both NEK7-to-partner and partner-to-NEK7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-650P grouped by NEK7-low versus NEK7-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NEK7→partner) and Y-score (partner→NEK7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	RNU6-650P →	+0.328	+5.038	.001	.009	3	2
COAD	BLOC1S2P1 →	+0.447	+5.080	<.001	.008	3	2
SKCM	RN7SL728P →	+0.100	+5.469	<.001	.002	3	2
UCEC	LINC00458 →	+0.152	+1.773	.008	.007	3	2
UCEC	RNA5SP413 →	+0.686	+1.862	.004	.004	3	2
SKCM	RSL24D1P2 →	+0.241	+4.531	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 645 associations by consensus.

RNU6-650P by NEK7 expression — BLCA

Explore this box plot interactively →