NEK7

Across TCGA patient cohorts, NEK7 mutation is significantly associated with the total protein of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NEK7-associated genes across cancer lineages are EGFR_pY1068, A-Raf_pS299, and FoxM1. Each is linked with NEK7 in more than 1 cancer types. Because this analysis shows association rather than direction, both NEK7-to-partner and partner-to-NEK7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by NEK7-low versus NEK7-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NEK7→partner) and Y-score (partner→NEK7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.263	-2.807	.016	.003	3	1
UCEC	A-Raf_pS299 →	-0.114	-3.000	.028	.036	3	1
UCEC	FoxM1 →	+0.311	+2.807	.005	.003	3	1
UCEC	INPP4B →	-0.369	-3.321	.008	.009	3	1
UCEC	JNK2 →	+0.260	+2.469	.002	.010	3	1
UCEC	Ku80 →	+0.209	+2.128	.043	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

EGFR_pY1068 by NEK7 expression — UCEC

Explore this box plot interactively →