NEK6

Across TCGA cell cohorts, NEK6 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,466 significant associations in total. CNS shows the largest number of these associations.

The most reproducible NEK6-associated GO terms across cancer lineages are Mitotic nuclear membrane disassembly, Negative regulation of fatty acid transport, and Response to oscillatory fluid shear stress. Each is linked with NEK6 in more than 12 cancer types. Because this analysis shows association rather than direction, both NEK6-to-partner and partner-to-NEK6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Mitotic nuclear membrane disassembly grouped by NEK6-low versus NEK6-high in URINARY_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (NEK6→partner) and Y-score (partner→NEK6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	Mitotic nuclear membrane disassembly →	+0.183	+1.334	<.001	<.001	3	13
LUNG_NSCLC_LUSC	Negative regulation of fatty acid transport →	+0.214	+1.748	<.001	<.001	3	13
KIDNEY	Response to oscillatory fluid shear stress →	+0.190	+1.415	.001	.001	3	13
KIDNEY	Cellular response to oscillatory fluid shear stress →	+0.190	+1.415	.001	.001	3	13
KIDNEY	Vascular endothelial cell response to oscillatory fluid shear stress →	+0.190	+1.415	.001	.001	3	13
LIVER	Positive regulation of establishment of T cell polarity →	+0.229	+1.108	.002	.007	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,466 associations by consensus.

Mitotic nuclear membrane disassembly by NEK6 expression — URINARY_TRACT

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