NEK6

Across TCGA cell cohorts, NEK6 mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NEK6-associated genes across cancer lineages are PLA2G5, ENPP6, and RBMY1J. Each is linked with NEK6 in more than 1 cancer types. Because this analysis shows association rather than direction, both NEK6-to-partner and partner-to-NEK6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PLA2G5 grouped by NEK6-low versus NEK6-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NEK6→partner) and Y-score (partner→NEK6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PLA2G5 →	+0.101	+3.994	<.001	.002	3	1
LARGE_INTESTINE	ENPP6 →	+0.035	+4.115	.001	.001	3	1
LARGE_INTESTINE	RBMY1J →	+0.006	+4.022	<.001	.006	3	1
LARGE_INTESTINE	ADAM7 →	+0.004	+3.345	<.001	.007	3	1
BLOOD_Leukemia	IFNA4 →	+0.058	+4.922	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

PLA2G5 by NEK6 expression — LARGE_INTESTINE

Explore this box plot interactively →