NEK5

mutation — cross-omics
Cross-omicsMUTATION → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, NEK5 mutation is significantly associated with the RNA expression of many other genes, with 3,489 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NEK5-associated genes across cancer lineages are CENPM, RHBDD3, and RPS19BP1. Each is linked with NEK5 in more than 2 cancer types. Because this analysis shows association rather than direction, both NEK5-to-partner and partner-to-NEK5 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NEK5→partner) and Y-score (partner→NEK5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
UCECCENPM →+0.551+2.369<.001<.00133
UCECRHBDD3 →+0.490+2.369<.001<.00133
UCECRPS19BP1 →+0.388+1.857<.001<.00133
UCECNEDD8-MDP1 →+0.184+1.723<.001<.00133
READHIKESHIP1 →+0.588+3.781<.001.00932
READDNM1P17 →+0.257+4.081<.001.00432
Each partner links to its Q-omics profile. Showing the 6 strongest of 3,489 associations by consensus.

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