NEK5

mutation — cross-omics
Cross-omicsMUTATION → PROTEIN-RPPAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, NEK5 mutation is significantly associated with the total protein of many other genes, with 37 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NEK5-associated genes across cancer lineages are EGFR_pY1068, Acetyl-a-Tubulin-Lys40, and p38-MAPK_pT180_Y182. Each is linked with NEK5 in more than 1 cancer types. Because this analysis shows association rather than direction, both NEK5-to-partner and partner-to-NEK5 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NEK5→partner) and Y-score (partner→NEK5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
UCECEGFR_pY1068 →-0.248-2.378.001<.00132
UCECAcetyl-a-Tubulin-Lys40 →+0.367+1.523.024.00832
UCECp38-MAPK_pT180_Y182 →-0.427-1.584.002.01732
UCECS6_pS240_S244 →+0.296+2.321.022.00532
UCECATM →-0.328-1.289.023.02332
UCEC4E-BP1_pT37_T46 →-0.359-2.986.002<.00132
Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

Exploration