NEK4

Across TCGA pan-cancer cohorts, NEK4 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated NEK4 data layer compared with 24 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher NEK4 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated NEK4 expression acts as an unfavorable survival marker.

LUAD, HNSC, and LSCC are the cancer types where NEK4 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Tertile	All	0.572	0.860	.006	18	view →
HNSC	DFS	Tertile	II,III,IV	0.490	0.801	.030	8	view →
LSCC	OS	Quartile	II,III,IV	0.818	1.000	.021	3	view →
CCRCC	OS	Median	II,III,IV	0.485	1.000	.036	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

NEK4–LUAD (OS)

Open the LUAD breakdown →