NEK4

Across TCGA patient cohorts, NEK4 mutation is significantly associated with the RNA expression of many other genes, with 855 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NEK4-associated genes across cancer lineages are GPT2, FEN1, and NIPA1. Each is linked with NEK4 in more than 1 cancer types. Because this analysis shows association rather than direction, both NEK4-to-partner and partner-to-NEK4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GPT2 grouped by NEK4-low versus NEK4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NEK4→partner) and Y-score (partner→NEK4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GPT2 →	+0.602	+2.008	<.001	.005	3	2
UCEC	FEN1 →	+0.607	+3.807	.001	<.001	3	2
UCEC	NIPA1 →	+0.650	+2.021	.001	.001	3	2
UCEC	THOP1 →	+0.459	+2.010	.001	.001	3	2
UCEC	MRTO4 →	+0.387	+2.595	.001	.005	3	2
LUAD	LINC02719 →	+0.208	+6.087	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 855 associations by consensus.

GPT2 by NEK4 expression — UCEC

Explore this box plot interactively →