NEK4

Across TCGA patient cohorts, NEK4 mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NEK4-associated genes across cancer lineages are S6_pS240_S244, 53BP1, and EGFR_pY1068. Each is linked with NEK4 in more than 1 cancer types. Because this analysis shows association rather than direction, both NEK4-to-partner and partner-to-NEK4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, S6_pS240_S244 grouped by NEK4-low versus NEK4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NEK4→partner) and Y-score (partner→NEK4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	S6_pS240_S244 →	+0.410	+1.700	.017	.044	3	2
UCEC	53BP1 →	+0.314	+2.321	.030	.034	3	2
UCEC	EGFR_pY1068 →	-0.229	-1.700	.031	.044	3	1
UCEC	eIF4E →	+0.242	+2.584	.006	.010	2	2
UCEC	A-Raf_pS299 →	-0.189	-3.459	<.001	.005	3	1
UCEC	FoxM1 →	+0.368	+2.906	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

S6_pS240_S244 by NEK4 expression — UCEC

Explore this box plot interactively →