NEK4

Across TCGA cell cohorts, NEK4 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,272 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible NEK4-associated GO terms across cancer lineages are P-body assembly, Regulation of DNA repair, and Regulation of double-strand break repair via homologous recombination. Each is linked with NEK4 in more than 16 cancer types. Because this analysis shows association rather than direction, both NEK4-to-partner and partner-to-NEK4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, P-body assembly grouped by NEK4-low versus NEK4-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (NEK4→partner) and Y-score (partner→NEK4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	P-body assembly →	+0.118	+0.777	.003	.001	3	17
SOFT_TISSUE	Regulation of DNA repair →	+0.061	+0.832	.003	.001	3	17
UPPER_AERODIGESTIVE_TRACT	Regulation of double-strand break repair via homologous recombination →	+0.097	+1.259	<.001	<.001	3	17
LARGE_INTESTINE	Microtubule nucleation →	+0.119	+0.942	<.001	<.001	3	16
BONE	Epigenetic regulation of gene expression →	+0.073	+0.642	.002	.003	3	15
LARGE_INTESTINE	Positive regulation of DNA metabolic process →	+0.065	+0.888	<.001	<.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,272 associations by consensus.

P-body assembly by NEK4 expression — BONE

Explore this box plot interactively →