NEK4

Across TCGA cell cohorts, NEK4 mutation is significantly associated with the RNA expression of many other genes, with 224 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NEK4-associated genes across cancer lineages are CBY1, CA2, and MANBA. Each is linked with NEK4 in more than 1 cancer types. Because this analysis shows association rather than direction, both NEK4-to-partner and partner-to-NEK4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CBY1 grouped by NEK4-low versus NEK4-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NEK4→partner) and Y-score (partner→NEK4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CBY1 →	+0.566	+3.299	.005	.004	3	1
LARGE_INTESTINE	CA2 →	+2.113	+3.087	<.001	.006	3	1
LARGE_INTESTINE	MANBA →	+0.745	+3.212	.004	.006	3	1
LARGE_INTESTINE	PCCB →	+0.640	+3.299	.001	.004	3	1
LARGE_INTESTINE	MRPS15 →	+0.516	+3.299	.001	.004	3	1
LARGE_INTESTINE	FBXL5 →	+0.494	+3.212	.007	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 224 associations by consensus.

CBY1 by NEK4 expression — LARGE_INTESTINE

Explore this box plot interactively →