NEK3

Across TCGA pan-cancer cohorts, NEK3 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated NEK3 data layer compared with 26 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher NEK3 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated NEK3 expression acts as an unfavorable survival marker, although some lineages such as PDAC and CCRCC show a favorable association.

HNSC, PDAC, and CCRCC are the cancer types where NEK3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Quartile	II,III,IV	0.683	0.951	<.001	40	view →
PDAC	OS	Quartile	II,III,IV	0.781	0.270	.003	24	view →
CCRCC	DFS	Median	III,IV	0.843	0.364	.004	21	view →
COAD	DFS	Median	II,III,IV	1.000	0.883	.023	6	view →
LSCC	OS	Median	II,III,IV	0.810	1.000	.035	1	view →
LUAD	OS	Quartile	All	0.788	0.944	.049	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

NEK3–HNSC (OS)

Open the HNSC breakdown →