NEK3

Across TCGA patient cohorts, NEK3 mutation is significantly associated with the RNA expression of many other genes, with 1,263 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NEK3-associated genes across cancer lineages are RNU6-47P, TMEM225, and RNA5SP411. Each is linked with NEK3 in more than 1 cancer types. Because this analysis shows association rather than direction, both NEK3-to-partner and partner-to-NEK3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-47P grouped by NEK3-low versus NEK3-high in GBM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NEK3→partner) and Y-score (partner→NEK3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	RNU6-47P →	+0.890	+5.149	<.001	.007	3	2
READ	TMEM225 →	+0.114	+5.039	<.001	.008	3	2
UCEC	RNA5SP411 →	+1.079	+1.756	<.001	.005	3	2
BLCA	LINC02107 →	+0.188	+5.106	<.001	.008	3	2
GBM	RNU6-1092P →	+0.751	+5.857	<.001	.002	3	1
GBM	CACNA1C-AS3 →	+0.249	+4.969	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,263 associations by consensus.

RNU6-47P by NEK3 expression — GBM

Explore this box plot interactively →