NEK3

Across TCGA patient cohorts, NEK3 mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NEK3-associated genes across cancer lineages are ATM, eIF4E, and FoxM1. Each is linked with NEK3 in more than 1 cancer types. Because this analysis shows association rather than direction, both NEK3-to-partner and partner-to-NEK3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by NEK3-low versus NEK3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NEK3→partner) and Y-score (partner→NEK3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.682	-3.700	<.001	.001	3	2
UCEC	eIF4E →	+0.164	+2.087	.042	.005	3	1
UCEC	FoxM1 →	+0.264	+2.469	.007	.010	3	1
UCEC	JNK2 →	+0.155	+1.678	.042	.023	3	1
UCEC	MEK1 →	+0.425	+2.807	.002	.003	3	1
UCEC	MIG-6 →	+0.086	+1.594	.024	.042	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

ATM by NEK3 expression — UCEC

Explore this box plot interactively →