NEK3

Across TCGA cell cohorts, NEK3 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,112 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible NEK3-associated GO terms across cancer lineages are Sulfur amino acid biosynthetic process, Blood coagulation, extrinsic pathway, and Positive regulation of muscle cell differentiation. Each is linked with NEK3 in more than 8 cancer types. Because this analysis shows association rather than direction, both NEK3-to-partner and partner-to-NEK3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Sulfur amino acid biosynthetic process grouped by NEK3-low versus NEK3-high in KIDNEY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (NEK3→partner) and Y-score (partner→NEK3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	Sulfur amino acid biosynthetic process →	+0.175	+0.740	.003	.009	2	9
OVARY	Blood coagulation, extrinsic pathway →	-1.007	-0.972	.001	.002	3	7
BLOOD_Leukemia	Positive regulation of muscle cell differentiation →	+0.115	+1.640	<.001	<.001	3	7
SKIN	Microtubule severing →	+0.063	+1.339	.001	.004	3	7
LARGE_INTESTINE	Endoplasmic reticulum mannose trimming →	+0.052	+0.658	.001	.004	3	7
BLOOD_Leukemia	Pentose-phosphate shunt, non-oxidative branch →	+0.098	+1.812	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,112 associations by consensus.

Sulfur amino acid biosynthetic process by NEK3 expression — KIDNEY

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