NEK2

Across TCGA patient cohorts, NEK2 mutation is significantly associated with the total protein of many other genes, with 34 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NEK2-associated genes across cancer lineages are 14-3-3_beta, eEF2, and EGFR_pY1068. Each is linked with NEK2 in more than 1 cancer types. Because this analysis shows association rather than direction, both NEK2-to-partner and partner-to-NEK2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by NEK2-low versus NEK2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NEK2→partner) and Y-score (partner→NEK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.080	-3.143	.026	.018	3	1
UCEC	eEF2 →	+0.426	+2.807	<.001	.003	3	1
UCEC	EGFR_pY1068 →	-0.330	-2.807	<.001	<.001	3	1
UCEC	eIF4E →	+0.221	+2.807	.003	.003	3	1
UCEC	ERK2 →	+0.203	+2.459	.003	.018	3	1
UCEC	FOXO3a_pS318_S321 →	-0.103	-1.896	.022	.015	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

14-3-3_beta by NEK2 expression — UCEC

Explore this box plot interactively →