NEK2

Across TCGA cell cohorts, NEK2 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,430 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible NEK2-associated GO terms across cancer lineages are Nuclear division, Metaphase chromosome alignment, and Regulation of chromosome condensation. Each is linked with NEK2 in more than 18 cancer types. Because this analysis shows association rather than direction, both NEK2-to-partner and partner-to-NEK2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Nuclear division grouped by NEK2-low versus NEK2-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (NEK2→partner) and Y-score (partner→NEK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Nuclear division →	+0.109	+1.373	<.001	<.001	3	19
UPPER_AERODIGESTIVE_TRACT	Metaphase chromosome alignment →	+0.132	+1.241	<.001	<.001	3	19
BLOOD_Myeloma	Regulation of chromosome condensation →	+0.216	+1.518	.003	.006	3	19
UPPER_AERODIGESTIVE_TRACT	Mitotic sister chromatid segregation →	+0.116	+1.212	.003	<.001	3	19
UPPER_AERODIGESTIVE_TRACT	Mitotic spindle organization →	+0.111	+1.452	<.001	<.001	3	19
UPPER_AERODIGESTIVE_TRACT	Chromosome segregation →	+0.122	+1.350	<.001	<.001	3	19

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,430 associations by consensus.

Nuclear division by NEK2 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →