NEK2

Across TCGA cell cohorts, NEK2 mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible NEK2-associated genes across cancer lineages are IFNG, SPATA19, and WFDC12. Each is linked with NEK2 in more than 1 cancer types. Because this analysis shows association rather than direction, both NEK2-to-partner and partner-to-NEK2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IFNG grouped by NEK2-low versus NEK2-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NEK2→partner) and Y-score (partner→NEK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	IFNG →	+0.233	+4.152	<.001	.009	3	1
BLOOD_Leukemia	SPATA19 →	+0.022	+5.569	<.001	.001	3	1
BLOOD_Leukemia	WFDC12 →	+0.244	+4.874	<.001	.002	3	1
BLOOD_Leukemia	OR6B3 →	+0.016	+4.539	<.001	.007	3	1
BLOOD_Leukemia	TRIM49B →	+0.158	+4.874	<.001	.002	3	1
BLOOD_Leukemia	TMEM244 →	+0.416	+4.551	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

IFNG by NEK2 expression — BLOOD_Leukemia

Explore this box plot interactively →