NEK11

Across TCGA pan-cancer cohorts, NEK11 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated NEK11 data layer compared with 27 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher NEK11 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated NEK11 expression acts as an unfavorable survival marker.

LSCC, LUAD, and GBM are the cancer types where NEK11 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	OS	Median	All	0.708	1.000	.018	9	view →
LUAD	DFS	Median	III,IV	0.395	0.719	.024	9	view →
GBM	OS	Tertile	All	0.745	0.912	.029	1	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

NEK11–LSCC (OS)

Open the LSCC breakdown →