NEK11

Across TCGA patient cohorts, NEK11 mutation is significantly associated with the total protein of many other genes, with 41 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NEK11-associated genes across cancer lineages are 4E-BP1, JNK_pT183_Y185, and ACC1. Each is linked with NEK11 in more than 2 cancer types. Because this analysis shows association rather than direction, both NEK11-to-partner and partner-to-NEK11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by NEK11-low versus NEK11-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NEK11→partner) and Y-score (partner→NEK11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	4E-BP1 →	+0.370	+3.000	.014	.035	3	3
UCEC	JNK_pT183_Y185 →	-0.153	-2.115	.008	.017	3	3
UCEC	ACC1 →	+0.304	+2.335	.016	.018	3	2
UCEC	PCNA →	+0.196	+2.222	.008	.010	3	2
UCEC	PDCD4 →	-0.534	-2.700	.001	.005	3	2
UCEC	Shc_pY317 →	-0.149	-2.070	.004	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 41 associations by consensus.

4E-BP1 by NEK11 expression — SKCM

Explore this box plot interactively →