NEK11

Across TCGA cell cohorts, NEK11 mutation is significantly associated with the RNA expression of many other genes, with 14 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible NEK11-associated genes across cancer lineages are FAM71A, ASB18, and USP17L15. Each is linked with NEK11 in more than 1 cancer types. Because this analysis shows association rather than direction, both NEK11-to-partner and partner-to-NEK11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FAM71A grouped by NEK11-low versus NEK11-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NEK11→partner) and Y-score (partner→NEK11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	FAM71A →	+0.074	+3.453	<.001	.009	3	1
BLOOD_Lymphoma	ASB18 →	+0.066	+5.643	<.001	.002	3	1
BLOOD_Lymphoma	USP17L15 →	+0.013	+6.247	<.001	<.001	3	1
BLOOD_Lymphoma	ARMS2 →	+0.041	+4.867	<.001	.009	3	1
CNS	KRTAP5-8 →	+0.064	+3.765	<.001	.008	3	1
SKIN	KRTAP19-8 →	+0.164	+4.415	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

FAM71A by NEK11 expression — LARGE_INTESTINE

Explore this box plot interactively →