NEK10

Across TCGA patient cohorts, NEK10 mutation is significantly associated with the RNA expression of many other genes, with 5,137 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NEK10-associated genes across cancer lineages are SDHB, PIMREG, and PPP2R2D. Each is linked with NEK10 in more than 3 cancer types. Because this analysis shows association rather than direction, both NEK10-to-partner and partner-to-NEK10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SDHB grouped by NEK10-low versus NEK10-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NEK10→partner) and Y-score (partner→NEK10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	SDHB →	+0.371	+3.199	.004	.009	3	4
UCEC	PIMREG →	+0.555	+1.343	.001	.001	3	4
UCEC	PPP2R2D →	+0.241	+3.001	<.001	<.001	3	4
COAD	ATP6V1FNB →	-0.778	-3.574	<.001	.002	3	3
UCEC	CCL4 →	+0.874	+2.173	<.001	<.001	3	3
UCEC	UHRF1 →	+0.918	+1.974	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,137 associations by consensus.

SDHB by NEK10 expression — COAD

Explore this box plot interactively →