NEK10

Across TCGA patient cohorts, NEK10 mutation is significantly associated with the total protein of many other genes, with 64 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NEK10-associated genes across cancer lineages are Caspase-7-cleavedD198, Stathmin, and PDCD4. Each is linked with NEK10 in more than 3 cancer types. Because this analysis shows association rather than direction, both NEK10-to-partner and partner-to-NEK10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by NEK10-low versus NEK10-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NEK10→partner) and Y-score (partner→NEK10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Caspase-7-cleavedD198 →	+1.186	+2.824	<.001	.034	3	3
SKCM	Stathmin →	+0.148	+2.087	.030	.005	3	3
UCEC	PDCD4 →	-0.287	-1.415	.034	.040	3	3
UCEC	Annexin-1 →	+0.505	+2.189	<.001	.001	3	3
UCEC	STAT3_pY705 →	-0.432	-1.954	<.001	<.001	3	3
UCEC	4E-BP1 →	+0.319	+3.247	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 64 associations by consensus.

Caspase-7-cleavedD198 by NEK10 expression — COAD

Explore this box plot interactively →