NEK10

Across TCGA cell cohorts, NEK10 mutation is significantly associated with the RNA expression of many other genes, with 140 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NEK10-associated genes across cancer lineages are IFNA10, IFNA7, and SPATA19. Each is linked with NEK10 in more than 1 cancer types. Because this analysis shows association rather than direction, both NEK10-to-partner and partner-to-NEK10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IFNA10 grouped by NEK10-low versus NEK10-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NEK10→partner) and Y-score (partner→NEK10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	IFNA10 →	+0.059	+5.539	<.001	.003	3	2
LUNG_SCLC	IFNA7 →	+0.255	+4.643	<.001	.004	3	2
KIDNEY	SPATA19 →	+0.036	+5.000	<.001	.005	3	1
BLOOD_Myeloma	SLITRK3 →	+0.325	+3.906	.007	.009	3	1
BLOOD_Myeloma	C16orf90 →	+0.035	+4.285	<.001	.003	3	1
LUNG_NSCLC_LUAD	P2RY13 →	+0.015	+4.312	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 140 associations by consensus.

IFNA10 by NEK10 expression — BLOOD_Leukemia

Explore this box plot interactively →