NEIL2

Across TCGA patient cohorts, NEIL2 RNA expression is significantly associated with the go_rna of many other GO terms, with 7,150 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible NEIL2-associated GO terms across cancer lineages are Protein localization to nucleolus, Protein localization to chromosome, telomeric region, and Protein poly-ADP-ribosylation. Each is linked with NEIL2 in more than 28 cancer types. Because this analysis shows association rather than direction, both NEIL2-to-partner and partner-to-NEIL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Protein localization to nucleolus grouped by NEIL2-low versus NEIL2-high in SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (NEIL2→partner) and Y-score (partner→NEIL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SCLC	Protein localization to nucleolus →	+0.117	+1.225	<.001	.005	2	29
CHOL	Protein localization to chromosome, telomeric region →	+0.037	+0.800	.009	.004	1	26
THYM	Protein poly-ADP-ribosylation →	+0.059	+0.664	<.001	<.001	3	24
SCLC	Maturation of 5.8S rRNA →	+0.096	+1.283	<.001	<.001	3	24
MESO	Positive regulation of DNA damage checkpoint →	+0.044	+0.497	.001	.001	2	24
SCLC	Late endosome to vacuole transport via multivesicular body sorting pathway →	+0.094	+1.347	<.001	<.001	3	23

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,150 associations by consensus.

Protein localization to nucleolus by NEIL2 expression — SCLC

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