NEIL2

Across TCGA patient cohorts, NEIL2 mutation is significantly associated with the RNA expression of many other genes, with 439 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NEIL2-associated genes across cancer lineages are IGHVIII-22-2, LINC01609, and MRPL57P7. Each is linked with NEIL2 in more than 1 cancer types. Because this analysis shows association rather than direction, both NEIL2-to-partner and partner-to-NEIL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IGHVIII-22-2 grouped by NEIL2-low versus NEIL2-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NEIL2→partner) and Y-score (partner→NEIL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	IGHVIII-22-2 →	+1.975	+5.588	<.001	.004	3	2
BLCA	LINC01609 →	+0.148	+4.973	<.001	.009	3	1
BLCA	MRPL57P7 →	+0.246	+5.497	<.001	.004	3	1
BLCA	DUXAP6 →	+0.128	+5.251	.005	.006	3	1
BLCA	THRAP3P2 →	+0.050	+6.147	<.001	.002	3	1
BLCA	MESTP2 →	+0.053	+5.788	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 439 associations by consensus.

IGHVIII-22-2 by NEIL2 expression — BLCA

Explore this box plot interactively →