NEIL2

Across TCGA patient cohorts, NEIL2 mutation is significantly associated with the total protein of many other genes, with 4 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NEIL2-associated genes across cancer lineages are MEK1, ASNS, and p62 Lck ligand. Each is linked with NEIL2 in more than 1 cancer types. Because this analysis shows association rather than direction, both NEIL2-to-partner and partner-to-NEIL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by NEIL2-low versus NEIL2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NEIL2→partner) and Y-score (partner→NEIL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.442	+3.000	.036	.037	3	1
UCEC	ASNS →	+0.701	+3.000	<.001	.036	2	1
UCEC	p62 Lck ligand →	+0.494	+3.000	.008	.037	1	1
UCEC	Cyclin-B1 →	+0.756	+3.000	.019	.037	1	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

MEK1 by NEIL2 expression — UCEC

Explore this box plot interactively →