NEGR1

Across TCGA pan-cancer cohorts, NEGR1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated NEGR1 data layer compared with 23 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher NEGR1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated NEGR1 expression acts as an unfavorable survival marker, although some lineages such as GBM and PDAC show a favorable association.

LUAD, GBM, and CCRCC are the cancer types where NEGR1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Median	II,III,IV	0.773	1.000	.005	23	view →
GBM	DFS	Tertile	All	0.496	0.302	.019	8	view →
CCRCC	DFS	Median	III,IV	0.399	0.932	.022	6	view →
LSCC	DFS	Tertile	II,III,IV	0.516	0.818	.019	6	view →
PDAC	OS	Tertile	III,IV	0.597	0.337	.037	5	view →
UCEC	DFS	Median	All	0.955	0.850	.034	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

NEGR1–LUAD (DFS)

Open the LUAD breakdown →