NEGR1

Across TCGA patient cohorts, NEGR1 mutation is significantly associated with the total protein of many other genes, with 61 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NEGR1-associated genes across cancer lineages are c-Met_pY1235, 4E-BP1_pT37_T46, and ACVRL1. Each is linked with NEGR1 in more than 2 cancer types. Because this analysis shows association rather than direction, both NEGR1-to-partner and partner-to-NEGR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, c-Met_pY1235 grouped by NEGR1-low versus NEGR1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NEGR1→partner) and Y-score (partner→NEGR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	c-Met_pY1235 →	+0.051	+1.402	.019	.011	3	3
SKCM	4E-BP1_pT37_T46 →	+0.542	+3.000	.018	.036	3	2
UCEC	ACVRL1 →	-0.090	-1.565	.025	.008	3	2
UCEC	p62 Lck ligand →	+0.376	+2.331	<.001	<.001	3	2
UCEC	PRAS40_pT246 →	+0.119	+1.584	.018	.017	3	2
UCEC	TFRC →	+0.408	+2.222	.009	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 61 associations by consensus.

c-Met_pY1235 by NEGR1 expression — UCEC

Explore this box plot interactively →