NEGR1

Across TCGA cell cohorts, NEGR1 mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible NEGR1-associated genes across cancer lineages are CLDN34, WDR87, and UCMA. Each is linked with NEGR1 in more than 1 cancer types. Because this analysis shows association rather than direction, both NEGR1-to-partner and partner-to-NEGR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CLDN34 grouped by NEGR1-low versus NEGR1-high in BLOOD_Myeloma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NEGR1→partner) and Y-score (partner→NEGR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	CLDN34 →	+0.043	+4.807	<.001	.006	3	1
LARGE_INTESTINE	WDR87 →	+0.021	+3.453	<.001	.009	3	1
SKIN	UCMA →	+0.071	+4.977	<.001	.007	3	1
SKIN	GLT6D1 →	+0.023	+5.415	<.001	.004	3	1
SKIN	TMEM114 →	+0.051	+4.977	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

CLDN34 by NEGR1 expression — BLOOD_Myeloma

Explore this box plot interactively →