NEFH

Across TCGA pan-cancer cohorts, NEFH mass-spec protein is linked to patient survival in 2 of 34 cancer types, making it a survival-associated NEFH data layer compared with 19 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in glioblastoma multiforme (GBM), where higher NEFH mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated NEFH expression acts as an unfavorable survival marker, although some lineages such as CCRCC show a favorable association.

GBM and CCRCC are the cancer types where NEFH mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
GBM	OS	Median	All	0.244	0.531	.018	6	view →
CCRCC	DFS	Median	III,IV	1.000	0.485	.040	4	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

NEFH–GBM (OS)

Open the GBM breakdown →