NEDD9

Across TCGA pan-cancer cohorts, NEDD9 mass-spec protein differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of NEDD9’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where NEDD9 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types NEDD9 is over-expressed in tumor, although a few such as LUAD and COAD show the opposite, repressed pattern.

HNSC, LUAD, and PDAC are the cancer types where NEDD9 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NEDD9 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	All	+0.815	<.001	9	view →
LUAD	Female	II,III,IV	−0.279	<.001	7	view →
PDAC	Female	All	+0.909	<.001	6	view →
CCRCC	All	II,III,IV	+0.266	.006	6	view →
COAD	Female	III,IV	−0.562	.009	5	view →
LSCC	Male	All	−0.152	.002	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

NEDD9–HNSC

Open the HNSC breakdown →