NEDD4

Across TCGA pan-cancer cohorts, NEDD4 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated NEDD4 data layer compared with 27 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher NEDD4 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated NEDD4 expression acts as an unfavorable survival marker, although some lineages such as HNSC show a favorable association.

LSCC, PDAC, and HNSC are the cancer types where NEDD4 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	OS	Tertile	II,III,IV	0.710	0.972	.001	52	view →
PDAC	DFS	Quartile	III,IV	0.291	0.886	.001	42	view →
HNSC	OS	Tertile	All	0.847	0.547	<.001	40	view →
LUAD	OS	Quartile	III,IV	0.415	0.830	.032	4	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

NEDD4–LSCC (OS)

Open the LSCC breakdown →