NEDD1

Across TCGA patient cohorts, NEDD1 mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NEDD1-associated genes across cancer lineages are Shc_pY317, ATM, and Caspase-8. Each is linked with NEDD1 in more than 1 cancer types. Because this analysis shows association rather than direction, both NEDD1-to-partner and partner-to-NEDD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Shc_pY317 grouped by NEDD1-low versus NEDD1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NEDD1→partner) and Y-score (partner→NEDD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Shc_pY317 →	-0.151	-1.906	.004	.015	3	2
UCEC	ATM →	-0.441	-1.807	.005	.025	3	2
UCEC	Caspase-8 →	-0.268	-4.143	.002	<.001	3	2
UCEC	4E-BP1 →	+0.250	+2.029	.007	.017	3	2
UCEC	EGFR_pY1068 →	-0.228	-2.070	.008	.001	3	1
UCEC	eIF4E →	+0.159	+2.598	.029	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

Shc_pY317 by NEDD1 expression — UCEC

Explore this box plot interactively →