NEDD1

Across TCGA cell cohorts, NEDD1 mutation is significantly associated with the RNA expression of many other genes, with 38 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NEDD1-associated genes across cancer lineages are OR6N1, GOLGA6C, and PRSS45P. Each is linked with NEDD1 in more than 1 cancer types. Because this analysis shows association rather than direction, both NEDD1-to-partner and partner-to-NEDD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR6N1 grouped by NEDD1-low versus NEDD1-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NEDD1→partner) and Y-score (partner→NEDD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	OR6N1 →	+0.226	+5.415	<.001	.004	3	1
BLOOD_Leukemia	GOLGA6C →	+0.055	+3.934	<.001	.005	3	1
BLOOD_Leukemia	PRSS45P →	+0.059	+3.855	<.001	.007	3	1
BLOOD_Leukemia	LCE1F →	+0.298	+4.384	<.001	.006	3	1
BLOOD_Leukemia	SERPINA2 →	+0.021	+4.384	<.001	.006	3	1
LARGE_INTESTINE	ASPA →	+0.398	+3.935	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

OR6N1 by NEDD1 expression — SKIN

Explore this box plot interactively →