NECTIN2

Across TCGA pan-cancer cohorts, NECTIN2 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated NECTIN2 data layer compared with 25 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher NECTIN2 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated NECTIN2 expression acts as an unfavorable survival marker, although some lineages such as LSCC and HNSC show a favorable association.

LSCC, PDAC, and HNSC are the cancer types where NECTIN2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Median	III,IV	1.000	0.599	.001	24	view →
PDAC	OS	Median	IV	0.381	0.951	.006	14	view →
HNSC	OS	Median	III,IV	1.000	0.484	.038	4	view →
GBM	DFS	Tertile	All	0.497	0.297	.025	2	view →
LUAD	OS	Median	II,III,IV	0.442	0.899	.015	2	view →
CCRCC	DFS	Tertile	II,III,IV	0.461	0.776	.047	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

NECTIN2–LSCC (DFS)

Open the LSCC breakdown →