NECTIN2

Across TCGA patient cohorts, NECTIN2 mutation is significantly associated with the RNA expression of many other genes, with 1,677 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NECTIN2-associated genes across cancer lineages are MIR6894, ACTG1P2, and OR51C1P. Each is linked with NECTIN2 in more than 2 cancer types. Because this analysis shows association rather than direction, both NECTIN2-to-partner and partner-to-NECTIN2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR6894 grouped by NECTIN2-low versus NECTIN2-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NECTIN2→partner) and Y-score (partner→NECTIN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	MIR6894 →	+0.629	+5.192	<.001	.001	3	3
BLCA	ACTG1P2 →	+0.057	+3.916	.003	.002	3	2
SKCM	OR51C1P →	+0.024	+4.328	<.001	<.001	3	2
SKCM	GLYATL3 →	+0.041	+3.169	.001	.003	3	2
SKCM	NHP2P2 →	+0.295	+3.195	<.001	.002	3	2
COAD	CYCSP46 →	+0.389	+3.496	<.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,677 associations by consensus.

MIR6894 by NECTIN2 expression — LUSC

Explore this box plot interactively →