NECTIN2

Across TCGA patient cohorts, NECTIN2 mutation is significantly associated with the total protein of many other genes, with 31 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NECTIN2-associated genes across cancer lineages are EGFR, ERK2, and JNK2. Each is linked with NECTIN2 in more than 1 cancer types. Because this analysis shows association rather than direction, both NECTIN2-to-partner and partner-to-NECTIN2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR grouped by NECTIN2-low versus NECTIN2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NECTIN2→partner) and Y-score (partner→NECTIN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR →	-0.146	-3.459	.008	.005	3	2
UCEC	ERK2 →	+0.211	+3.700	.001	.001	3	2
UCEC	JNK2 →	+0.247	+2.594	<.001	.006	3	2
UCEC	p70-S6K_pT389 →	-0.159	-2.321	.015	.005	3	2
UCEC	Annexin-1 →	+0.410	+2.479	.024	.010	3	2
UCEC	STAT3_pY705 →	-0.229	-2.311	.012	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

EGFR by NECTIN2 expression — UCEC

Explore this box plot interactively →