NECTIN2

Across TCGA cell cohorts, NECTIN2 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,084 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible NECTIN2-associated GO terms across cancer lineages are Positive regulation of natural killer cell mediated immune response to tumor cell, Positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, and Glial cell differentiation. Each is linked with NECTIN2 in more than 17 cancer types. Because this analysis shows association rather than direction, both NECTIN2-to-partner and partner-to-NECTIN2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of natural killer cell mediated immune response to tumor cell grouped by NECTIN2-low versus NECTIN2-high in BLOOD_Leukemia.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (NECTIN2→partner) and Y-score (partner→NECTIN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	Positive regulation of natural killer cell mediated immune response to tumor cell →	+1.054	+2.120	<.001	<.001	3	18
BLOOD_Leukemia	Positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target →	+0.912	+2.525	<.001	<.001	3	18
STOMACH	Glial cell differentiation →	+0.083	+2.051	<.001	.002	3	15
BLOOD_Leukemia	Fusion of virus membrane with host plasma membrane →	+1.180	+2.537	<.001	<.001	3	15
BLOOD_Leukemia	Membrane fusion involved in viral entry into host cell →	+1.180	+2.537	<.001	<.001	3	15
BONE	Negative regulation of calcium ion export across plasma membrane →	+0.106	+1.323	<.001	<.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,084 associations by consensus.

Positive regulation of natural killer cell mediated immune response to tumor cell by NECTIN2 expression — BLOOD_Leukemia

Explore this box plot interactively →