NECTIN1

Across TCGA pan-cancer cohorts, NECTIN1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated NECTIN1 data layer compared with 26 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher NECTIN1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated NECTIN1 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and PDAC show a favorable association.

CCRCC, PDAC, and OV are the cancer types where NECTIN1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Tertile	All	0.948	0.533	<.001	29	view →
PDAC	OS	Median	IV	0.836	0.431	.017	6	view →
OV	DFS	Median	All	0.815	1.000	.017	4	view →
GBM	DFS	Tertile	All	0.804	0.652	.040	1	view →
LSCC	DFS	Quartile	All	0.986	0.858	.035	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

NECTIN1–CCRCC (DFS)

Open the CCRCC breakdown →