NECTIN1

Across TCGA patient cohorts, NECTIN1 RNA expression is significantly associated with the protein abundance of many other proteins, with 16,013 significant associations in total. GBM shows the largest number of these associations.

The most reproducible NECTIN1-associated proteins across cancer lineages are NECTIN1_S422, ARHGEF6_S684, and DENND5B_S1076. Each is linked with NECTIN1 in more than 5 cancer types. Because this analysis shows association rather than direction, both NECTIN1-to-partner and partner-to-NECTIN1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, NECTIN1 versus NECTIN1_S422 in UCEC, with a Pearson correlation of 0.54.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (NECTIN1→partner) and Y-score (partner→NECTIN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	NECTIN1_S422 →	+0.796	+0.851	<.001	<.001	3	6
LSCC	ARHGEF6_S684 →	-0.495	-0.863	<.001	<.001	3	5
LSCC	DENND5B_S1076 →	-0.796	-1.239	<.001	<.001	3	5
BRCA	FSCN1 →	+0.583	+0.936	<.001	<.001	3	5
HNSC	PKN1 →	-0.276	-1.147	<.001	<.001	3	5
UCEC	VSNL1 →	+1.577	+1.360	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 16,013 associations by consensus.

NECTIN1 vs NECTIN1_S422 — UCEC

Explore this scatter interactively →